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Molecular modeling and antimycobacterial studies of Mannich bases: 5-hydroxy-2-methyl-4H-pyran-4-ones
Antimycobacterial activity DNA gyrase activity hydroxy-4H-pyran-4-one homology modeling
2011/4/6
The World Health Organization lists tuberculosis among the top 3 leading causes of death from a single infectious agent, and reported cases of multidrug-resistant tuberculosis (MDR-TB) are on the rise...
Some New Mannich Bases of 5-Methyl-2-Benzoxazolinones With Analgesis and Anti-Inflammatory Activities
5-Methyl-2-Benzoxazolinone Mannich Reaction Analgesic Anti-inflammatory Activities
2010/4/20
The synthesis of a novel series of Mannich bases of 5-methyl-3-substituted piperazinomethyl-2-benzoxazolinones is described. The structures attributed to compounds 3c, 3d and 3f-3n were elucidated usi...
Synthesis of Mannich Bases of Some 2,5-Disubstituted 4-Thiazolidinones and Evaluation of Their Antimicrobial Activities
2,5-Disubstituted 4-thiazolidinones synthesis Mannich bases antimicrobial activity
2010/4/20
4-Carbethoxymethyl-2-[(a -chloropropionyl/a -bromobutyryl/a-chloro-(a-phenyl)acetyl)amino]thiazoles (2a-c) were synthesized by the reaction of 4-carbethoxymethyl-2-aminothiazole (1) with a-chloropropi...
Synthesis and Reactivity of Some Mannich Bases. VI. New Arylamine Mannich Bases Derived From 2-Hydroxy-5-Methylacetophenone
Mannich bases amine-exchange reaction arylamines b-arylaminoketones ortho-hydroxyacetophenones
2010/6/29
The amine exchange reaction has been applied for obtaining a new series of arylamine Mannich bases from variously substituted aromatic amines and 3-(dimethylamino)-1-(2'-hydroxy-5'-methylphenyl) propa...