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Reactive Heterocycles for Examining Polyketide Biosynthesis
beta-lactam fluorescent polyketide site-specific labeling
2014/11/20
Polyketides are a class of natural products that exhibit remarkable structural and functionally diversity and are highly sought after due to their medicinally important activities. For many decades no...
Synthesis and Characterization of Novel Azole Heterocycles Based on 2,5-Disubstituted Thiadiazole
1,3,4-thidiazoles fused heterocyclic ring Schiff bases
2010/4/16
Starting from 2-amino-5-mercapto-1,3,4-thiadiazole (1), a variety of new 1,2,4-triazino[5,4-b][1,3,4] thiadiazole (3), pyrazole (4), [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazole (5), phthalazine-3,6-dion...
Fused Heterocycles: Synthesis of Some New Imidazopyridines as Anti-Mycobacterial Agents
Imidazo[1 2-a]pyridine semicarbazones 4-thiazolidinone antituberculous activity
2010/4/8
The reaction of semicarbazones bearing an imidazo[1,2-a]pyridine ring system with mercaptoacetic acid was investigated. The anti-mycobacterial activity of the compounds thus obtained were evaluated ag...
Synthesis of Nitrogen-Containing Heterocycles from the Reaction of Amidrazones with a-Haloesters
Amidrazones a-haloesters 4,5-dihydro-1,2,4-triazin-6-one
2010/4/16
The reaction of amidrazones 1 with a-haloesters 2 formed 1,3,5-substituted 4,5-dihydro-1,2,4-triazin-6-ones (4a-z) rather than 1,2,4-triazin-5-one derivatives (5a-z). The microanalysis and spectral da...
Heterocyclic Synthesis Using Nitrilimines: Part 5. Synthesis of Some Novel Spiro Heterocycles
Cycloaddition benzoylhydrazones nitrilimines spiro-triazoles
2010/4/19
A new class of spiro-triazoles (4a-m) were synthesized from the reaction of corresponding nitrilimines 2 with substituted heterocyclic benzoylhydrazones 3 in good yields. The spectral data of the new ...