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Design and Implementation of a Laboratory-Based Drug Design and Synthesis Advanced Pharmacy Practice Experience
APPE research drug design synthesis medicinal chemistry
2018/8/17
Objective. To provide students with an opportunity to participate in medicinal chemistry research within the doctor of pharmacy (PharmD) curriculum.
Design. We designed and implemented a 3-course seq...
Synthesis of metronidazole derivatives as antigiardiasis agents
Metronidazole Giardiasis Imidazole Epoxide
2010/4/6
Metronidazole (MTZ) and its derivatives have been extensively used to treat infections caused by protozoa and anaerobic bacteria. In this investigation several novel imidazole and nitroimidazol deriva...
Synthesis and in vitro dual calcium channel antagonist-agonist activity of some 1, 4-Dihydo-2,6-dimethyl-3-nitro and cyano-4-(1-methyl-5-nitro-1H-imidazol-2-yl)-5-pyridinecarboxylates
Calcium channel antagonist-agonist activity Dihydropyridines QSAR
2009/12/14
Background and purpose of the study: The vasorelaxant action of the dihydropyridines (DHPs) provides many useful clinical indications. However, their negative effects on cardiac contractility is still...
SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 2-AMINO-5-[4-CHLORO-2-(2-CHLOROPHENOXY) PHENYL]-1,3,4-THIADIAZOLE DERIVATIVES
1,3,4-thiadiazole Anticonvulsant activity Maximal electroshock
2010/4/9
Several novel 2-amino-5-[4-chloro-2-(2-chlorophenoxy)phenyl]-1,3,4-thiadiazole derivatives 4a-d were synthesized and their anticonvulsant activity was determined by evaluation of the ability of theses...