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近日，山东大学公共卫生学院孙强教授和山东省肿瘤医院王家林研究员团队在医学Top期刊Cancer上发表了题为“Long-term Effectiveness of One-time Endoscopic Screening for Esophageal Cancer: A Community-Based Study in Rural China”的研究论文，定量化揭示了食管癌内镜筛查效果的显著性和持...
Simulation-based Parameter Estimation for Complex Models: A Breast Cancer Natural History Modelling Illustration
Simulation-based Parameter Estimation Complex Models Breast Cancer Natural History Modelling Illustration
2015/7/6
Simulation-based parameter estimation offers a powerful means of estimating parameters in complex stochastic models. We illustrate the application of these ideas in the setting of a natural history mo...
A Stochastic Simulation Model of US Breast Cancer Mortality Trends from 1975 to 2000
Stochastic Simulation Model Breast Cancer Mortality Trends
2015/7/6
Background: We present a simulation model that predicts U.S. breast cancer mortality trends from 1975 to 2000 and quantifi es the impact of screening mammography and adjuvant therapy on these trends. ...
A Natural History Model of Stage Progression Applied to Breast Cancer
natural history model stage progression breast cancer SEER tumour growth
2015/7/6
Invasive breast cancer is commonly staged as local, regional or distant disease. We present a stochastic model of the natural history of invasive breast cancer that quantifies (1) the relative rate th...
From GWAS to transcriptomics in prospective cancer design - new statistical challenges
Post -GWAS Transcriptomics Nested case -control Functional changes Biomarkers
2013/4/27
Background. With the increasing interest in post-GWAS research which represents a transition from genome-wide association discovery to analysis of functional mechanisms, attention has been lately focu...
A sparse regulatory network of copy-number driven expression reveals putative breast cancer oncogenes
sparse regulatory network copy-number driven expression reveals
2010/10/19
The influence of DNA cis-regulatory elements on a gene's expression has been intensively studied. However, little is known about expressions driven by trans-acting DNA hotspots. DNA hotspots harborin...
An integrative analysis of cancer gene expression studies using Bayesian latent factor modeling
micro-environmental parameters in cancer Weibull survival models
2010/10/19
We present an applied study in cancer genomics for integrating data and inferences from laboratory experiments on cancer cell lines with observational data obtained from human breast cancer studies. T...
A Proposed Architecture for Implementing a Knowledge Management System in the Brazilian National Cancer Institute
knowledge management information system health care hospital management
2009/9/25
Because their services are based decisively on the collection, analysis and exchange of clinical information or knowledge, within and across organizational boundaries, knowledge management has excepti...
Bayesian Hierarchical Multiresolution Hazard Model for the Study of Time-Dependent Failure Patterns in Early Stage Breast Cancer
Multiresolution models Bayesian survival analysis hazard estimation
2009/9/22
In this paper, we extend the previously proposed MRH methods(Bouman et al.2005, 2007) into the hierarchical multiresolution hazard setting (HMRH), to accommodate the case of separate hazard rate funct...
Statistical models to study subtoxic concentrations for some standard mutagens in three colon cancer cell lines
Inverse regression problem subtoxic concentration confidence interval
2009/2/23
The aim of this work is to propose models to study the toxic effect of different concentrations of some standard mutagens in different colon cancer cell lines. We find estimates and, by means of an in...
Radiation Pollution and Cancer：Comparative Risks and Proof
Radiation Pollution Cancer electromagnetic waves
2008/12/17
One of the most important physical phenomena in our universe is
the existence of electromagnetic waves. They consist of electric and
magnetic fields rapidly reversing in direction and propagating
t...
Cancer’s Uncertainties and Public Policy
Public Policy toxic waste disposal environmental pollution
2008/12/17
An unusually intractable policy problem of environmental pollution
and toxic waste disposal is how to deal with the risk of chemically
induced cancer. Many features of this issue make this policy ta...
This paper investigates the effect of health insurance on health and the use of health services by exploiting a change in insurance status that occurs for most Americans at age 65; that is, eligibilit...