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Simulation-based Parameter Estimation for Complex Models: A Breast Cancer Natural History Modelling Illustration
Simulation-based Parameter Estimation Complex Models Breast Cancer Natural History Modelling Illustration
2015/7/6
Simulation-based parameter estimation offers a powerful means of estimating parameters in complex stochastic models. We illustrate the application of these ideas in the setting of a natural history mo...
A Stochastic Simulation Model of US Breast Cancer Mortality Trends from 1975 to 2000
Stochastic Simulation Model Breast Cancer Mortality Trends
2015/7/6
Background: We present a simulation model that predicts U.S. breast cancer mortality trends from 1975 to 2000 and quantifi es the impact of screening mammography and adjuvant therapy on these trends. ...
A Natural History Model of Stage Progression Applied to Breast Cancer
natural history model stage progression breast cancer SEER tumour growth
2015/7/6
Invasive breast cancer is commonly staged as local, regional or distant disease. We present a stochastic model of the natural history of invasive breast cancer that quantifies (1) the relative rate th...
A sparse regulatory network of copy-number driven expression reveals putative breast cancer oncogenes
sparse regulatory network copy-number driven expression reveals
2010/10/19
The influence of DNA cis-regulatory elements on a gene's expression has been intensively studied. However, little is known about expressions driven by trans-acting DNA hotspots. DNA hotspots harborin...
Bayesian Hierarchical Multiresolution Hazard Model for the Study of Time-Dependent Failure Patterns in Early Stage Breast Cancer
Multiresolution models Bayesian survival analysis hazard estimation
2009/9/22
In this paper, we extend the previously proposed MRH methods(Bouman et al.2005, 2007) into the hierarchical multiresolution hazard setting (HMRH), to accommodate the case of separate hazard rate funct...
This paper investigates the effect of health insurance on health and the use of health services by exploiting a change in insurance status that occurs for most Americans at age 65; that is, eligibilit...