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乳腺癌作为女性最常见的癌症，是一种多因素导致的疾病，约70%的乳腺癌呈雌激素受体α阳性（ERα+）。靶向ERα信号通路的内分泌疗法是ERα+乳腺癌临床治疗的重要方式，但易产生耐药问题，导致针对单一靶点的抗乳腺癌药物无法满足临床需求。临床联合用药在一定程度上提高了癌症治疗效果并降低了耐药性，但药物之间的相互作用可能会带来一些不可预知的毒副作用。相比之下，多靶点药物被认为是一种更理想的乳腺癌治疗策略，...
山东大学药学院刘新泳教授团队在Journal of Medicinal Chemistry发表新型HIV-1 NNRTIs的研究新成果（图）
刘新泳 教授 新型 HIV-1 NNRTIs 药物化学
2021/4/21
近期，山东大学药学院刘新泳教授团队在国际药物化学领域顶级期刊《药物化学杂志》（Journal of Medicinal Chemistry）发表了题为“2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallograph...
山东大学药学院方浩教授课题组在Journal of Medicinal Chemistry发表最新研究成果（图）
山东大学药学院 方浩 Journal of Medicinal Chemistry 药物化学杂志 HDAC 蛋白酶体 骨髓瘤
2020/4/27
近期，山东大学药学院方浩教授课题组在国际药物化学领域顶级期刊《药物化学杂志》（Journal of Medicinal Chemistry）发表了题为“Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Re...
云南大学教育部自然资源药物化学重点实验室林军团队/金毅副研究员连续在European Journal of Medicinal Chemistry上发表抗肿瘤治疗药物的最新研究成果（图）
金毅副研究员 药物化学 血管内皮细胞
2022/9/22
近日，云南大学教育部自然资源药物化学重点实验室林军教授团队联合昆明理工大学生命科学院张继虹教授课题组、昆明医科大学肿瘤医院李科副教授课题组及昆明制药集团药物研究院等多家单位，在连续两期国际著名药物化学Top期刊European Journal of Medicinal Chemistry （IF：4.833，药物化学一区）中刊发了抗肿瘤药物研究领域的最新研究进展。
近日，长三角绿色制药协同创新中心阮奔放教授谷氨酰胺酶抑制剂新药研发创新团队以我校为第一作者单位、长三角绿色制药协同创新中心博士研究生陈钊和药学院硕士研究生李迪等为并列第一作者、药学院阮奔放教授为通讯作者，在药物化学领域顶级期刊Journal of Medicinal Chemistry上发表了一篇题为“Novel 1,3,4-Selenadiazole Containing Kidney-Type...
Antihyperlipidemic Statins: A Self-Contained, Clinically Relevant Medicinal Chemistry Lesson
medicinal chemistry dyslipidemia hyperlipidemia statins
2018/4/9
Medicinal chemistry instruction at Creighton University is designed to provide an in-depth, scientifically grounded and clinically relevant learning experience for pharmacy students. Each topic covere...
The Importance of Medicinal Chemistry Knowledge in the Clinical Pharmacist’s Education
Importance Medicinal Chemistry Knowledge Clinical Pharmacist’s Education
2018/11/21
Objective. To show why medicinal chemistry must be a key component of the education of pharmacy students, as well as in the pharmacist’s practice.
Findings. Five case reports were selected by their c...
3rd RSC-BMCS symposium on mastering medicinal chemistry
medicinal chemistry drug discovery
2017/1/19
In the main there are two types of drug discovery programmes: those that hit serious problems and those that are going to hit serious problems. The difference between success and failure is how we, as...
第二届世界卫生药物化学研讨会（2nd Symposium on Medicinal Chemistry for World Health）
Medicinal Chemistry drug discovery
2017/1/19
The meeting will take place within the Tres Cantos laboratories of GSK, near Madrid, Spain. Bringing together leading exponents for an exciting spread of themed sessions, the meeting will appeal to an...
2017药物化学戈登学术会议（The 2017 Gordon Research Conference on Medicinal Chemistry）
Medicinal Chemistry therapeutic areas
2017/1/18
Applications for this meeting must be submitted by July 9, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be st...
2017药物化学和化学生物学研讨会（Symposia on Medicinal Chemistry and Chemical Biology）
2017 药物化学和化学生物学 研讨会
2017/1/13
Medicinal chemistry and chemical biology are stimulating fields that connect many scientific disciplines and allow for collaboration with other scientists in a wide variety of opportunities. The objec...
西南大学化学化工学院周成合教授成果论文在药物化学顶级刊物《Journal of Medicinal Chemistry》发表
西南大学化学化工学院 教授 成果论文 药物化学顶级刊物 Journal of Medicinal Chemistry
2016/6/16
近日，西南大学化学化工学院周成合教授与来自印度化学技术研究院的博士后Addla Dinesh博士及其博士生崔胜峰的研究论文“Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism”在药物化学顶级期刊Journal of...
Integrating a New Medicinal Chemistry and Pharmacology Course Sequence into the PharmD Curriculum
medicinal chemistry pharmacology integration alignment curriculum
2018/7/24
Objective. To evaluate the implementation of an integrated medicinal chemistry/pharmacology course sequence and its alignment with a therapeutics series.
Design. Each topic was divided into modules c...
Test-Enhanced Learning in an Immunology and Infectious Disease Medicinal Chemistry/Pharmacology Course
test-enhanced learning retrieval practice curriculum assessment
2018/9/4
Objective. To develop a series of active-learning modules that would improve pharmacy students’ performance on summative assessments.
Design. A series of optional online active-learning modules conta...
A Three-Year Study of the Impact of Instructor Attitude,Enthusiasm,and Teaching Style on Student Learning in a Medicinal Chemistry Course
instructor enthusiasm science courses medicinal chemistry student learning
2018/7/10
Objective. To determine the effect of instructor attitude, enthusiasm, and teaching style on learning for distance and campus pharmacy students.
Methods. Over a 3-year period, distance and campus stu...