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以1H，4H-6-硝基吡唑［4,3-c］并吡唑-3-羧酸为起始原料，经过一步脱羧硝化反应得到1H,4H-3,6-二硝基吡唑[JP]［4,3-c］并吡唑（DNPP），收率76.7％，然后与硝酸铅、3,6-二肼基-1,2,4,5-四嗪反应合成了DNPP碱式铅盐（Pb-DNPP）与DNPP的3,6-二肼基-1,2,4,5-四嗪含能离子盐（DHT-DNPP）。采用红外光谱、1H NMR、13C NMR、质...
Molecular modeling and antimycobacterial studies of Mannich bases: 5-hydroxy-2-methyl-4H-pyran-4-ones
Antimycobacterial activity DNA gyrase activity hydroxy-4H-pyran-4-one homology modeling
2011/4/6
The World Health Organization lists tuberculosis among the top 3 leading causes of death from a single infectious agent, and reported cases of multidrug-resistant tuberculosis (MDR-TB) are on the rise...
Synthesis and characterization of novel triazol compounds containing a thiophen ring as potential antifungal agents and the structure of 2-(2-hydroxy-2-p-tolyethyl)-5-(thiophen-2-ylmethyl)- 4-(4H-1,2,4-triazol-4-yl)-2H-1,2,4-triazol-3(4H)-one
Synthesis 1,2,4-triazole-3-one NaBH4 LiAlH4 antimicrobial activity
2010/10/18
A series of new 4-(3,5-disubstitue-4H-1,2,4-triazol-4-yl)- 5-(thiophen-2-yl-methyl)-2H-1,2,4-triazol-3(4H)-ones (3a-c) were obtained by reaction N'-1-ethoxy-2-thiophen-2-yl-ethylydene hydrazino carbox...
Mannich base derivatives of 3-hydroxy-6- methyl-4H-pyran-4-one with antimicrobial activity
Antimycobacterial and antibacterial activity DNA gyrase activity
2010/10/18
A series of 3-hydroxy-6-methyl-2-[(substitutedpiperidine-1-yl) methyl]-4H-pyran-4-one structured compounds were synthesized by reacting 5-hydroxy-2-methyl-4H-pyran-4-one with suitable piperidine deriv...
Synthesis, structural determination, and biological activity of new 7-hydroxy-3-pyrazolyl-4H-chromen- 4-ones and their o-b-D-glucosides
Chromones pyrazoles glucopyranosyl bromide glucosylation
2010/10/15
A convenient route to synthesize some new medicinally important 7-hydroxy-3-pyrazolyl chromones (3a-i) is described. The interaction of 7-hydroxy-3-formyl chromone (1) with various substituted acetoph...
4H-Pyran-4-one derivatives:; leading molecule for preparation of compounds with antimycobacterial potential
Antimycobacterial activity DNA gyrase activity hydroxy-4H-pyran-4-one
2010/4/8
A series of 3-hydroxy-6-methyl-2-((4-substitutedpiperazin-1- yl)methyl)-4H-pyran-4-one structured compounds were synthesized by reacting 5-hydroxy-2-methyl-4H-pyran-4-one with suitable piperazine deri...
FTIR监测7-氟-2H-1,4-苯并噁嗪-3(4H)-酮的固相合成
组合化学 固相有机合成 红外光谱
2008/11/6
我们已经合成了一系列具有生物活性的杂环取代苯并噁嗪酮类化合物, 为了构建一个苯并噁嗪酮类化合物的组合物库, 我们又探索出了一种固相合成7-氟-2H-1,4-苯并噁嗪-3(4H)-酮的方法, 并用FTIR技术成功地监测、优化了整个反应过程, 并根据得到的红外光谱图对反应动力学进行了探讨.
Synthesis of Some New 4-oxo-4H-Chromene Derivatives Bearing Nitrogen Heterocyclic Systems as Antifungal Agents
Chromone nitrogen heterocycles antifungal activity
2010/4/16
Some new 4-oxo-4H-chromone derivatives bearing nitrogen heterocyclic systems were achieved by treatment of 3-[(4-aminophenylimino) methyl]-6-chloro-4-oxo-4H-chromene (2) with some aldehydes, cyclic ox...
一维链状的2-氧-1(4H)-吡啶氮乙酸钴配位聚合物{[Co(2-OPA)2(4，4′-bipy)(H2O)2]·6H2O}n的合成、结构及性能研究
钴配位聚合物 晶体结构 热稳定性 荧光性能
2008/3/20
一维链状的2-氧-1(4H)-吡啶氮乙酸钴配位聚合物{[Co(2-OPA)2(4，4′-bipy)(H2O)2]·6H2O}n的合成、结构及性能研究。
Synthesis and Characterizations of Some New 4H-1,2,4-Triazole Derivatives
4H-1,2,4-triazole 1,3,4-thiadiazole 1,3-benzoxazole salicyl aldehyde acetylation acrylonitrile acrylic acid
2010/4/16
3-[(5-Amino-1,3,4-thiadiazol-2-yl)methyl]-4-ethoxycarbonylamino-5-alkyl-4H-1,2,4-triazoles (2a,b) were obtained from the reaction of 3-cyanomethyl-5-alkyl-4-ethoxycarbonylamino-4H-1,2,4-triazoles (1a...
亚苄基氰基乙酸乙酯(1)与5,5-二甲基-1,3-环已二酮在乙二醇中不加任何催化剂于80℃反应2～3h得2-氨基-4-芳基-7,7-二甲基-5-氧化-4H-5,6,7,8-四氢苯并-[b]-吡喃-3-羧酸乙酯(3)，产率75%～93%。
水相中2-氨基-4-芳基-5,6-二氢化-4H-吡喃并[3,2-c]喹啉-5-酮衍生物的合成
吡喃并喹啉 水 TE 合成
2007/12/24
摘要 以芳亚甲基丙二腈或2-氰基-3-芳基丙烯酸酯和4-羟基喹啉-2-酮为原料, 水为溶剂, 在TEBA(三乙基苄基氯化铵)催化下90 ℃, 合成了2-氨基-4-芳基-5,6-二氢化-4H-吡喃[3,2-c]喹啉-5-酮衍生物. 和其它方法相比, 该反应具有反应条件温和, 产率高(87%～96%)和环境友好等优点. 产物的结构通过熔点, IR, 1H NMR和元素分析表征. 化合物3m的结构通过X...
摘要 三唑硫醚类化合物具有多种重要的生理活性，本文设计合成了一系列三甲氧基苯基取代的三唑硫醚衍生物，目标化合物由4-苯基-5-(3,4,5-三甲氧基苯基)-4H-1,2,4-三唑-3-巯基化合物与不同的卤代物在三氯化铟催化下于水相中反应，得到3-(取代甲基硫基)-4-苯基-5-(3,4,5-三甲氧基苯基)-4H-1,2,4-三唑衍生物，合成方法具有环境友好、操作简单、合成收率高等特点。
顺（反）-2，4，7-三芳基5-氧代4H-5，6，7，8-四氢苯并吡喃衍生物的合成
2007/12/23
摘要 在酸或碱怀条件下，5，5-二甲基-1，3-环已二酮和5-芳基-1，3-环已二酮与 查尔酮首先进行Michael加成反应，进而环合为7，7-二甲基-2，4-二芳基-5-氧代- 4H-5，6，7，8-四氢苯并吡喃衍生物和含有两个手性原子的顺和反-2，4，7-三芳 基-5-氧代-4H-5，6，7，8-四氢苯并吡喃衍生物。讨论了反应机理并且通过~1H NMR光谱和NOE差谱确定其产物构型。所合成新的...