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Classify hyperdiploidy status of multiple myeloma patients using gene expression profiles
Classify hyperdiploidy status multiple myeloma patients expression profiles
2016/1/25
Multiple myeloma (MM) is a cancer of antibody-making plasma cells. It frequently harbors alterations in DNA and chromosome copy numbers, and can be divided into two major subtypes, hyperdiploid (HMM) ...
The shaping and functional consequences of the dosage effect landscape in multiple myeloma
shaping functional consequences dosage effect landscape multiple myeloma
2016/1/25
In this paper we study the conditional limit theorems for critical continuous-state branching processes with branching mechanism ψ(λ) = λ 1+α L(1/λ)where α ∈ [0,1] and L is slowly varying at ∞. We pro...
Transcription factor-pathway co-expression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma
coexpression cell cycle arrest multiple myeloma hyperdiploid
2016/1/25
Multiple myeloma is a hematological cancer of plasma B cells and remains incurable. Two major subtypes of myeloma, hyperdiploid MM (HMM) and non-hyperdiploid MM (NHMM), have distinct chromosomal alter...
Classify hyperdiploidy status of multiple myeloma patients using gene expression profiles
Classify hyperdiploidy status multiple myeloma patients expression profiles
2016/1/20
Multiple myeloma (MM) is a cancer of antibody-making plasma cells. It frequently harbors alterations in DNA and chromosome copy numbers, and can be divided into two major subtypes, hyperdiploid (HMM) ...
Transcription factor-pathway co-expression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma
coexpression cell cycle arrest multiple myeloma hyperdiploid
2016/1/20
Multiple myeloma is a hematological cancer of plasma B cells and remains incurable. Two major subtypes of myeloma, hyperdiploid MM (HMM) and non-hyperdiploid MM (NHMM), have distinct chromosomal alter...
Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis: systematic review and meta-regression
multiple sclerosis relapses annualized relapse rates placebo baseline characteristics eligibility criteria meta-analysis meta-regression systematic review
2013/4/27
Background: Recent studies have shown a decrease in annualised relapse rates (ARRs) in placebo groups of randomised controlled trials (RCTs) in relapsing multiple sclerosis (RMS).
Methods: We conduc...
Multistage tests of multiple hypotheses
Closed testing Family-wise error rate Multiple hypothesis testing
2011/7/19
Conventional multiple hypothesis tests use step-up, step-down, or closed testing methods to control the overall error rates.
Omni-tomography/Multi-tomography -- Integrating Multiple Modalities for Simultaneous Imaging
Tomography CT MRI PET SPECT US imaging optical imaging functional imaging
2011/7/6
Current tomographic imaging systems need major improvements, especially when multi-dimensional, multi-scale, multi-temporal and multi-parametric phenomena are under investigation.
A nonparametric empirical Bayes framework for large-scale multiple testing
Dirichlet process marginal likelihood mixture model
2011/7/6
We propose a flexible and identifiable version of the two-groups model, motivated by hierarchical Bayes considerations, that features an empirical null and a semiparametric mixture model for the non-n...
Adjusting for selection bias in testing multiple families of hypotheses
false discovery rate family-wise error rate hierarchical testing
2011/7/6
In many large multiple testing problems the hypotheses are divided into families. Given the data, families with evidence for true discoveries are selected, and hypotheses within them are tested.