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替代每日口服药物，HIV首个长效注射治疗方案在中国获批
口服药物 注射治疗 利匹韦林注射液
2023/11/8
近日，英国药企葛兰素史克（GSK）宣布，其HIV（人类免疫缺陷病毒，由该病毒引起的疾病被称为“艾滋病”）药物专研合资公司ViiV Healthcare的产品万凯锐?（通用名称：卡替拉韦注射液），与美国强生旗下杨森制药有限公司产品瑞卡必?（通用名称：利匹韦林注射液），已获得中国国家药品监督管理局（NMPA）批准联合使用，用于治疗已达到病毒学抑制的HIV-1感染者。
2022年6月10日，中国医学科学院医药生物技术研究所岑山研究团队在Nucleic Acids Research在线发表了最新研究成果“Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery”的研究论文，本研究发现SL...
Food insecurity, but not HIV-infection status, is associated with adverse changes in body composition during lactation in Ugandan women of mixed HIV status
BMI body composition postpartum pregnancy Uganda
2018/11/12
Background: Body composition is an important indicator of nutritional status and health. How body composition changes during 12 mo of breastfeeding in HIV-infected women receiving antiretroviral thera...
Young (2005) argues that HIV related population declines reinforced by the fertility
response to the epidemic will lead to higher capital-labor ratios and to higher per capita
incomes in the a ected...
Estimating the Impact of Medical Innovation:A Case Study of HIV Antiretroviral Treatments
HIV AIDS antiretrovirals innovation Medicaid
2015/7/17
As health care consumes a growing share of GDP, the demand for better evidence regardingthe effects of health care treatments and how these vary across individuals is increasing. Estimatingthis with o...
Education, HIV, and Early Fertility: Experimental Evidence from Kenya
Education subsidies sexually transmitted infections AIDS venereal diseases
2015/7/17
A seven-year randomized evaluation suggests education subsidies reduce adolescent girls’ dropout, pregnancy, and marriage but not sexually transmitted infection (STI). The government’s HIV curriculum,...
Applying the Care Delivery Value Chain:HIV/AIDS Care in Resource Poor Settings
Customer Value and Value Chain Framework Health Care and Treatment Health Disorders Service Delivery
2015/4/23
The care delivery value chain is a framework that can help conceptualize the organization and structure of care delivery for medical conditions. We apply this framework to HIV/AIDS care in resource-l...
A Dynamic Theory of Fidelity Networks with an Application to the Spread of HIV/AIDS
Fidelity networks female discrimination stochastic stability HIV/AIDS union formation
2014/12/26
We study the dynamic stability of (in)Ödelity networks, which are networks that form in a mating system of agents of two types (say men and women), where each agent desires direct links with oppo...
Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya
medication adherence HIV children Western Kenya
2014/12/11
Background: Kenya experienced a political and humanitarian crisis following presidential elections on 27 December 2007. Over 1,200 people were killed and 300,000 displaced, with disproportionate viole...
HIV蛋白酶抑制剂的关键中间体——手性氨基环氧烷合成研究进展
HIV蛋白酶抑制剂 手性氨基环氧烷 合成
2014/4/24
拟肽类HIV蛋白酶抑制剂是临床治疗艾滋病的主要药物，它们的共性结构片段——(2R, 3S)-3-氨基-4-苯基-2-丁醇从关键中间体手性氨基环氧烷得到，笔者对该中间体的合成研究进行归纳和总结。
Preferential Targeting of HIV Infected Hubs in a Scale-free Sexual Network
HIV/AIDS scale-free network antiretroviral therapy circumcision
2014/8/8
The structure of sexual networks plays a role in the spread of HIV. If the structure of a sexual network can be identified and the highly susceptible people (hubs) targeted, then public health i...
Co-Occurring HIV Risk Behaviors among Males Entering Jail
HIV risk co-occurring behaviors correctional facilities male detainees
2013/4/28
This paper examines the pattern of HIV risk behaviors among male jail detainees. From multivariate analyses of baseline data from an HIV intervention study of ours, we find that: (1) cocaine use, hero...
采用分子全息定量构效关系(HQSAR)方法, 研究了34个HIV-1逆转录酶抑制剂S-DABOs类化合物的结构与活性之间的关系. 讨论了分子碎片大小、碎片区分参数以及分子全息长度对模型的影响. 以26个化合物构成的训练集所建最优模型的交叉验证相关系数q2为0.755, 相关系数r2 为0.949. 对8个化合物构成的测试集进行了预测, 其预测相关系数rpred2为0.95, 表明所建模型不仅有较高...
Anti-retroviral therapy for HIV: who should we test and who should we treat?
Anti-retroviral therapy for HIV who should we test who should we treat?
2012/9/18
In most countries CD4+ cell counts are still used for deciding when to start HIV-positive people on anti-retroviral therapy. However, various CD4+ thresholds, 200, 350 or 500/ μL, are chosen arbitrar...